Napoli vs Pisa Prediction and Betting Tips closes out Monday night’s Serie A action at the Stadio Diego Armando Maradona. After a bruising 2-0 defeat to Manchester City midweek, Antonio Conte’s champions now turn their focus back home, where they’ve looked flawless. In this article, you’ll discover Serie A Predictions from the XpertStats tipsters.

• Napoli return to Serie A after a tough Champions League defeat against Manchester City.
• Pisa still searching for their first league win since promotion.
• Kevin De Bruyne and Giovanni Di Lorenzo both under the spotlight for Napoli.
• First top-flight meeting in Naples between these two sides in over three decades.

Napoli may have stumbled in Europe, but they’ve been near untouchable in Italy. Three wins from three, six goals scored, and just two conceded, Conte’s team are making an early statement. Can they really slip at home against a newly-promoted Pisa side? That feels unlikely, especially given Napoli’s streak of 15 unbeaten in Serie A stretching back to February. Kevin De Bruyne will be itching to make amends after a subdued return to Manchester, while captain Giovanni Di Lorenzo has his own point to prove following his costly red card in midweek.

Conte does have some selection headaches, though. Romelu Lukaku is still sidelined, and Amir Rrahmani’s absence leaves the defense thinner than he’d like. That said, the likes of Lorenzo Lucca, once a Pisa player himself, could step in to add another layer of intrigue. Napoli’s home form is frightening, six wins in their last seven at Maradona, and history is firmly on their side.

Pisa, meanwhile, walk into a storm. Alberto Gilardino’s team are back in Serie A after 34 years, but so far, they’ve looked out of their depth. One point in three games, no goals scored from open play, and their only strike coming via an Atalanta own goal. That’s not the kind of firepower you need when facing the champions. Can Gilardino find a solution? Maybe M’Bala Nzola, pushing for his first start, is the answer, but even that feels like a long shot.

Still, Pisa have shown they can dig in defensively. A narrow 1-0 defeat to Roma and another tight loss to Udinese prove they’re not just rolling over. But heading to Naples is another beast entirely. Their last visit here was back in 1990, when Maradona himself found the net in a 2-1 win. Fitting, then, that the stadium now carries his name. Pisa will hope history doesn’t repeat, but facing a Napoli side hungry to bounce back, it’s hard to picture anything other than a long, difficult night. For tipsters and bettors alike, this looks like one-way traffic. Expect the champions to control it from start to finish. That’s why many lean towards Serie A Predictions heavily favoring the home side.