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Betis vs Lyon Prediction Europa League 06.11.2025

Alexandru Florin 5 November 2025

Betis vs Lyon Prediction Europa League

Betis vs Lyon Prediction and Betting Tips for Matchday 4 of the Europa League, scheduled for Thursday, November 6, 2025, at 20:00 GMT. The showdown unfolds at the Estadio de La Cartuja, with live coverage on Amazon Prime, TNT Sports 5, and Discovery+. Both sides have everything to fight for as the group phase reaches a crucial point. In this article, you’ll find detailed insights powered by Europa League Stats from XpertStats tipsters.

Real Betis host Lyon on Thursday, November 6, 2025, in a key Europa League group clash.
Both sides are unbeaten in Europe, but Lyon’s defense has yet to be breached.
Betis come in full of goals after a dominant domestic run under Pellegrini.
Lyon’s away form raises questions, can they hold firm in Seville?

Real Betis head into this fixture with quiet confidence. They’ve been steady in Europe so far: one win, two draws and now need a victory to climb the group table. Their 0-0 draw against Genk showed discipline, but the lack of finishing left Pellegrini frustrated. Still, at home, Betis look dangerous. Ten goals in two recent matches, including a 3-0 league win over Mallorca, show their firepower. Antony’s resurgence has been huge, and with Lo Celso returning to form, the Andalusians could cause Lyon serious problems. Can they finally turn possession into points? That’s the real question here.

On the flip side, Lyon have been almost flawless in Europe. Three wins from three, no goals conceded, those are the numbers that make fans dream. Paulo Fonseca has found the right balance between patience and punch, and Tolisso’s leadership in midfield has been key. But their Ligue 1 campaign tells another story: inconsistency, red cards, and patchy away form. That mix of brilliance and fragility makes this trip to Seville fascinating. If Lyon can keep their composure, they’ve got every chance of maintaining their perfect run.

Team news adds another layer of intrigue. Betis are still missing Isco, while Ricardo Rodriguez remains doubtful. For Lyon, Tessmann’s injury limits their attacking depth, and Mangala’s absence weakens the defensive midfield shield. It’s a test of squad depth and adaptability. Both sides are likely to start strong and aggressive, knowing that an early goal could define the night. Even so, the tactical duel between Pellegrini’s control and Fonseca’s discipline might just steal the show.

Ultimately, this matchup feels too close to call. Betis’ home form and Lyon’s defensive solidity almost cancel each other out. Expect moments of chaos, flashes of brilliance, and maybe a few nerves from both dugouts. The stats don’t lie, both teams know how to find the net. And that’s what makes this game one of the highlights of this week’s Europa League Stats action.

Real Betis coach Manuel Pellegrini has confirmed a 22-man squad to face Olympique Lyon in the UEFA Europa League, with Ricardo Rodríguez joining the list of absentees. The Swiss defender, who recently returned from injury, will miss the match alongside Isco, Junior Firpo, and Pau López. Amrabat and Chimy Ávila are back in the lineup, as Betis aim for a crucial result at La Cartuja. Source: Marca.

Both Teams to Score @1.66
Both Betis and Lyon enter this clash with proven attacking credentials. Betis have scored 10 goals in their last two matches, led by Antony’s dynamic form and Lo Celso’s creativity. At home, they rarely fail to score, finding the net in four of their last five matches. Lyon, meanwhile, are unbeaten in Europe with three wins out of three, scoring five and showing that their frontline: Tolisso, Sulc, and Satriano, can create chances even away from home. While Lyon’s defense has been impressive, their domestic form shows cracks when put under pressure, especially away. Betis’ offensive momentum combined with Lyon’s counter-attacking pace suggests this won’t be a one-sided game. Given both teams’ current rhythm and the stakes involved, it’s hard to see either keeping a clean sheet in Seville. Expect both to score, and possibly early.