Atletico Madrid vs Royale Union Prediction and Betting Tips for Matchday 4 of the UEFA Champions League, scheduled for Tuesday, November 4, 2025, at 20:00 GMT. The match will be played at the Metropolitano Stadium and broadcast live on Amazon Prime, Discovery+ and TNT Sports 5. Both teams are desperate for a result after recent setbacks, and in this article, you’ll find expert insights and Champions League Predictions from XpertStats analysts.

• Atletico Madrid look to maintain their formidable home record in the Champions League.
• Union Saint-Gilloise travel to Spain after back-to-back heavy defeats in Europe.
• Both sides have three points after three matches, making this a pivotal encounter.
• Julian Alvarez continues his strong scoring form for the hosts.

Atletico Madrid’s European journey hasn’t been smooth sailing so far. Three games in, just three points on the board, not what fans expected from a side with Simeone’s pedigree. Their only win came in a roaring 5-1 demolition of Eintracht Frankfurt, but the away losses to Liverpool and Arsenal exposed some defensive cracks. Still, the Metropolitano has been a fortress. Just one loss in their last sixteen Champions League home games says plenty. With Julian Alvarez firing and Griezmann potentially returning to the starting XI, there’s belief that Los Colchoneros can turn the tide. Can they find consistency when it matters most?

Domestically, Atletico are cruising. Fourth in La Liga, unbeaten in nine of their last ten matches, and fresh off a 3-0 win over Sevilla, they look confident again. Simeone’s tactics are clicking, and the midfield trio of Koke, Baena, and Gonzalez is creating balance between aggression and control. Alvarez’s 12 goal contributions this season underline his importance, while Sorloth’s presence adds a different kind of chaos. Even so, fatigue could play a role, with rotation expected. That said, few teams enjoy a midweek visit to the Metropolitano and Royale Union will soon find out why.

For Union Saint-Gilloise, this campaign has been a reality check. Their debut Champions League run began brightly with a 3-1 win over PSV Eindhoven, but the next two games were brutal: 0-4 defeats against Newcastle and Inter Milan. Nine goals conceded in three games is a statistic that tells its own story. Still, the Belgians aren’t lacking heart. Under new coach David Hubert, they’ve been flying domestically, top of the Pro League table, scoring freely, and defending stoutly. Marc Giger and Promise Akinpelu have been in electric form, and they’ll hope to carry that into Madrid. But will that attacking flair hold up under Simeone’s pressure machine?

Union’s challenge lies in experience. This is their first-ever meeting with Atletico Madrid and their first trip to Spain in European competition. The Belgian champions will fight, no doubt, but Madrid’s intensity, crowd, and tactical edge might be too much. The stats paint a clear picture Atletico average over two goals per game across their last nine fixtures, while Union’s European away form remains shaky. The smart money? On the hosts to dominate, both in possession and on the scoreboard. To explore more in-depth data and trends, check out the latest Champions League Stats.