AC Milan vs Lazio Prediction and Betting Tips for the Serie A showdown, scheduled for Saturday, November 29, 2025, at 19:45 GMT. The match will be broadcast live on DAZN and Discovery+ from the Stadio Giuseppe Meazza in Milan. Milan enter this fixture just two points off top spot, fresh from a gritty 1-0 derby victory over Inter. Lazio, meanwhile, got their groove back with a home win against Lecce and five clean sheets in six matches. For more insight across Italy’s top flight, explore Serie A Predictions from XpertStats tipsters.

• AC Milan aim to climb to the top of the Serie A table before Roma and Inter play on Sunday.
• Lazio have recorded five clean sheets in their last six matches but struggle away from home.
• Pulisic’s fitness remains uncertain after his Derby della Madonnina heroics last week.
• Expect a tactical showdown between Allegri and Sarri, two of Serie A’s sharpest minds.

It’s been a confident stretch for Milan. Allegri’s men haven’t lost in 12 games and have quietly built one of Serie A’s most resilient defenses, conceding just once per match on average. Mike Maignan’s performance in the derby was nothing short of heroic, pulling off impossible saves that could’ve changed the story. Still, the absence of Christian Pulisic might sting, the American has been decisive with 16 club goals this year. Can Leao and Nkunku carry the creative load in his place? That’s the big question echoing through Milanello this week.

On the other side, Lazio are starting to look like a side rediscovering their edge. After a messy start to the season, plagued by a transfer ban and injury setbacks, Sarri’s group have finally stabilized. The Biancocelesti boast a tight back line, conceding only 0.83 goals per match. However, their away form remains a headache. Nearly 300 minutes without scoring on the road paints a worrying picture, especially against a Milan defense that thrives on clean sheets. Still, Sarri’s side rarely go down easy. The tactical chess match between him and Allegri might be where this battle is truly decided.

Expect a physically intense game. Both teams average over 25 fouls per match, and the cards follow accordingly, Milan’s games see an average of 4.83 cards, Lazio’s 5.33. That’s not a coincidence. Both midfields are combative, both backlines disciplined yet prone to last-ditch tackles. A high-card count feels almost inevitable. But when emotions run high, moments of brilliance often sneak through. Whether that’s Leao cutting in from the left or Zaccagni snapping the drought for Lazio, this one could hinge on a single spark.

Even so, Milan’s current form and home advantage might be too much for Lazio to handle. The Rossoneri have won 67% of their matches with over 1.5 goals and remain consistent under pressure. Lazio’s defensive grit might keep them in the contest, but their lack of away goals could prove fatal. It’s hard to see Milan losing this one, but in Serie A, certainty is a luxury. For now, Milan look like the safer pick in this tight, tactical clash of ambitions and endurance, a true test for both sides in this year’s Serie A Predictions.